Vitamin B6 occurs in 3 forms–pyridoxine, pyridoxal, and pyridoxamine. B6 is absorbed in the large intestine. The muscle stores more or less 75-80 % of the vitamin even though the live stores approximately 5-10 %.
B6 is required for transaminations, decarboxylations, dehydratases, side-chain cleavage reactions, and ammonia release. Its aldehyde class functions as a Schiff base to react with the amino groups of amino acids. It basically acts to shuttle nitrogen between compounds.
Functions- The 3 types of B6 can all be switched into on the coenzyme PLP which aids in transamination & protein metabolism. PLP is essential for glycogen degradation; it also helps with the formation of the neurotransmitter, serotonin, the nonprotein portion of hemoglobin (heme), nucleic acids, and lecithin. Vitamin B6 is essential for the metabolic process of tryptophan to niacin.
· Transaminations These responses are needed to recycle as well as reuse nitrogen in the entire body. They’re the first phase in amino acid catabolism as well as the very last phase in the synthesis of nonessential amino acids. Example: a-ketoglutarate + asparate glutamate + oxaloacetate
· Serine/ Threonine Deamination (Dehydratases) This response supplies the generation of the a-keto acids of serine as well as threonine through oxidative removal of N as ammonia Example: Serine a-keto-serine + NH4+
· Decarboxylation These reactions often occur on the neuroactive amines of seratonin, tyramine, histamine, and GABA. They also are crucial in porphyrin synthesis, intermediates within the synthesis of sphingomyelin, taurine and lecithin, and also for the breakdown and desulfuration of cysteine.
· Glycogen Phosphorylase 50 % of all B6 within the body is certain to glycogen phosphorylase but the value is unknown. The response is important for recycling of folate and is as follows:
Serine glycine + 5,10-methylene-THF
Deficiency Deficiencies of vitamin B6 are fairly uncommon. Individuals with a diet deficient in vitamin B6 will 1st show signs of weakness, nervousness, insomnia, irritability, and hydrated skin lesions. Much more advanced symptoms include growth failure, impaired motor function, hypochromic microcytic anemia, smooth tongue, and convulsions.
The impaired motor performance along with other psychological problems could be linked to a decrease in amino acid-based neurotransmitters (serotonin, GABA, tyramine, epinephrine). meal preps delivered see a growth in urea excretion because of a decline synthesis of nonessential amino acids. The nitrogen from these amino acids is not recycled by transamination and instead is excreted and also lost. You see a rise in urinary excretion particularly in the succeeding amino acids: metabolites of glycine, methionine, & tryptophan. The hypochromic microcytic anemia is mainly because that there’s a decreased synthesis of the B6 dependent porphyrin ring of hemoglobin.
People who are at most risk include the older folk with inadequate vitamin intake, alcoholics, hemodialysis patients, and those who are on drug therapy. General, individuals with a high metabolic stress.
Sources Foods richest in vitamin B6 include:
o whole grains o legumes o nuts o navy beans o walnuts o meat (sirloin and chicken) o fish (salmon and shellfish) o bananas along with apples o broccoli and spinach
Therapeutics Vitamin B6 might provide healing advantages for the second syndromes: carpal tunnel syndrome, glucose intolerance, sideroblastic anemia, neurologic problems, hyperoxaluria, convulsive seizures, monosodium glutarate (MSG) intolerance, premenstral syndrome (pms) and Immune function. Furthermore, vitamin B6 might help decrease homocysteine levels and thus the risk of getting cardiovascular disease.